Health conditions

Menopause & Perimenopause

The natural transition when the ovaries wind down reproductive hormones.

Summary

What’s changing, which markers to track, and when it’s worth testing.

Symptoms

Irregular cycles, hot flashes, night sweats, disrupted sleep, mood changes, brain fog.

Menopause isn’t a moment — it’s a transition that unfolds over years, often starting in the early-to-mid 40s. Cycles shift, sleep changes, and symptoms arrive that can feel confusingly unconnected. Measuring what’s actually happening hormonally turns a vague, unsettling phase into something you can see, name, and manage.

What it is

Perimenopause is the transition: the ovaries gradually respond less, estradiol swings unpredictably, and FSH climbs as the body compensates. Menopause itself is defined simply — twelve months without a period. The years around it are where most of the symptoms live, and where most of the confusion does too, because cycles can still be present while everything else is shifting.

Signs and symptoms

Irregular or skipped periods, hot flashes and night sweats, sleep that fragments, mood swings, anxiety that arrives without a story, brain fog, vaginal dryness, and changes in skin and hair. Every woman’s mix is different — and because these symptoms overlap with stress, thyroid issues, and simply being busy, many women spend years wondering rather than knowing.

What you can track at home

FSH is the clearest measurable signal: it rises as the ovaries wind down, and a consistently elevated level alongside symptoms points to the transition being underway. Estradiol and LH complete the picture — estradiol’s decline explains many symptoms, and the hormones move in a recognizable pattern. A home FSH test won’t date your final period, but it converts “is this perimenopause?” from a guess into a data point.

When to see a doctor

Bring your results and your symptom pattern to a provider if symptoms disrupt sleep, work, or wellbeing — there are real, evidence-based options, from hormone therapy to targeted treatments, and suffering through is not a requirement. See a doctor promptly for bleeding that’s very heavy, lasts much longer than usual, or returns after twelve months without a period.

The average age of menopause is 51 — and the transition can begin up to a decade earlier.

References

  1. The American College of Obstetricians and Gynecologists. The Menopause Years.acog.org
  2. Harlow SD, et al. Executive summary of the Stages of Reproductive Aging Workshop +10 (STRAW+10).Menopause. 2012;19(4):387–395.
  3. The Menopause Society. Menopause 101.menopause.org

Related biomarker

  • Follicle-Stimulating Hormone (FSH)

    Follicle-Stimulating Hormone (FSH)

    Rises as the ovaries wind down — a core signal of the menopause transition.

    Learn more
  • Estradiol

    Estradiol

    Central to cycle, mood, bone, and heart health.

    Learn more
  • Luteinizing Hormone (LH)

    Luteinizing Hormone (LH)

    Surges roughly a day before ovulation — the signal ovulation tests read.

    Learn more