Biomarkers
Ketones in Urine
A sign of fat-burning — expected on keto, important to watch in diabetes.
Molecules your body makes when it burns fat for fuel.
Ketones are what your body produces when it runs on fat instead of carbohydrates. For someone on a low-carb or ketogenic plan, seeing them is the point. For someone with diabetes, high ketones are a warning sign that needs attention. Same molecule, very different meaning — context is everything.
What ketones are
When carbohydrate intake drops — through fasting, a ketogenic diet, or prolonged exercise — the liver converts fat into ketones to fuel the body and brain. Excess ketones leave through urine, which is what a test strip picks up.
Why levels change
Diet is the biggest lever: the fewer carbs you eat, the more ketones you’ll typically produce. Exercise, illness, and pregnancy also move levels. In diabetes, ketones can rise dangerously when the body lacks insulin — especially alongside high blood sugar — a condition called diabetic ketoacidosis that needs urgent medical care.
What a result can tell you
If you’re following a ketogenic plan, urine ketones confirm you’ve shifted into fat-burning and help you see how food choices affect it. If you have diabetes, a ketone check during illness or unexplained high glucose gives you an early warning — and a reason to contact your care team promptly if levels are moderate or high.
What it can’t tell you
Urine ketones lag behind blood levels by a few hours, and hydration dilutes or concentrates the reading. Long-term keto adapters may also excrete fewer ketones despite being in ketosis. If you have diabetes and readings are climbing, don’t interpret alone — that’s a call to your provider.
References
- Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes.Diabetes/Metabolism Research and Reviews. 1999;15(6):412–426.
- American Diabetes Association. Diabetes & DKA (Ketoacidosis).diabetes.org









